https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1890 Sat 24 Mar 2018 08:33:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15982 -/- mice had reduced infection, inflammation, and mucus-secreting cell hyperplasia. Surprisingly, infection of wild-type (WT) mice did not increase IL-13 production but reduced IL-13Rα2 decoy receptor levels compared with sham-inoculated controls. Infection of WT but not Il13^-/- mice induced persistent AHR. Infection and associated pathology were restored in infected Il13^-/- mice by reconstitution with IL-13. Stat6^-/- mice were also largely protected. Neutralization of IL-13 during infection prevented subsequent infection-induced severe AAD. Thus, early-life Chlamydia respiratory infection reduces IL-13Rα2 production, which may enhance the effects of constitutive IL-13 and promote more severe infection, persistent AHR, and AAD.]]> Sat 24 Mar 2018 08:23:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13282 Sat 24 Mar 2018 08:15:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12215 Sat 24 Mar 2018 08:12:07 AEDT ]]>